Mechanism of complex fractionated atrial electrograms in persistent atrial fibrillation

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461055
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: University of Tsukuba
• Principal Investigator: MURAKOSHI Nobuyuki 筑波大学, 医学医療系, 講師 (80447218)
• Co-Investigator(Renkei-kenkyūsha): XU Dongzhu 筑波大学, 医学医療系, 助教 (20616651) ; NOGAMI Akihiko 筑波大学, 医学医療系, 教授 (80708602)
• Research Collaborator: YAMAGAMI Fumi 筑波大学, 人間総合科学研究科 ; FENG Duo 筑波大学, 人間総合科学研究科
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 心房細動 / 不整脈 / 臨床心臓学 / 連続性分裂電位

Outline of Final Research Achievements

Complex fractionated atrial electrograms (CFAEs) are likely to be observed in the atrial electrocardiogram from patients with persistent atrial fibrillation. CFAE-like electrical activity was observed in atrial cardiomyocytes co-cultured with cardiac fibroblast after tachypacing stimulation or treatment with angiotensin II. Intracellular calcium overload was seen in such area, and calcium-handling molecules were dynamically altered. Sodium-calcium exchanger expression was increased, calcium/calmodulin-dependent kinase II, ryanodine receptor II, and sarcoplasmic reticulum ATPase 2a were hyperactiveted, and gap junction proten connexin 40 expression was decreased, which were suggested to contribute to the formation and perpetuation of CFAE.

Free Research Field

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