Impact of vasodilatory capacity of the coronary microcirculation on improvement of left ventricular function after valve replacement in patients with aortic stenosis

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461058
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Kanazawa University
• Principal Investigator: Sakata Kenji 金沢大学, 附属病院, 講師 (20456411)
• Co-Investigator(Renkei-kenkyūsha): MORI MIKA 金沢大学, 附属病院, 特任助教 (80467109) ; GAMOU TADATSUGU 金沢大学, 附属病院, 助教 (10579634)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 大動脈弁狭窄症 / 心筋内微小循環

Outline of Final Research Achievements

The purpose of this study was to investigate the vasodilatory capacity of the coronary microcirculation on improvement of left ventricular function after valve replacement in patients with low-flow aortic stenosis. The index of microvascular resistance (IMR) and resistive reserve ratio (RRR) before valve replacement were not significantly different between the groups with and without improvement of % changes in stroke volume index (SVI) six month after valve replacement. In the setting of normal-flow aortic stenosis before surgery, IMR was significantly higher in the group with improvement of SVI than those without. In contrast, in the setting of low-flow aortic stenosis before surgery, IMR and RRR were not significantly different between the two groups. In conclusion, the indices of vasodilatory capacity of the coronary microcirculation before surgery were not different between groups with and without improvement of left ventricular function.

Free Research Field

医師薬学