long term outcome by reduced impairment of coronary endothelial function after new generation drug-eluting stent implantation

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461059
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: University of Yamanashi
• Principal Investigator: OBATA Jyun-Ei 山梨大学, 総合研究部, 講師 (60362076)
• Research Collaborator: UMETANI Ken ; OGAWA Ryuji ; ODA Hirotaka ; ONODERA Tomoya ; SAKAMOTO Hiroki ; SAWANOBORI Takao ; TAKAHASHI Minoru ; TANAKA Hiroyuki ; NAKAMURA Sunao ; NAKAMURA Masashi ; HIGUCHI Kotaro ; MATSUMURA Kuniyoshi ; YAMADA Ayano ; WATANABE Akinori
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 冠動脈内皮機能障害 / 薬剤溶出性ステント

Outline of Final Research Achievements

We examined the time course of coronary endothelial dysfunction after drug-eluting stent (DES) implantation, and evaluated whether it influence on cardiac function and long term clinical outcome. Vasomotor function of the infarct-related coronary artery and left ventricular function were measured at 2 weeks and 6 months after stent implantation in patients with acute anterior myocardial infarction. More than 4000 patients registered in the Yamanashi PCI (percutaneous coronary intervention) Registry, which was constructed with our 14 affiliated facilities, were followed for long term clinical outcome. At 2 weeks after stent implantation, endothelial dysfunction was less in the 2nd DES compared with 1st DES. Furthermore, the recovery of it was better in the 2nd DES compared with 1st DES at six months later. Because the follow-up periods were not enough, we could not conclude the long-term outcome. So, we will follow up our study patients, and present some data in the near future.

Free Research Field

虚血性心疾患