Therapeutic angiogenesis using adipose-derived regenerative cell

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461062
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Shinshu University
• Principal Investigator: IKEDA Uichi 信州大学, 医学部, 特任教授 (30221063)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 末梢動脈疾患 / 血管再生療法 / 脂肪組織由来幹細胞

Outline of Final Research Achievements

Clinical studies and basic research on angiogenesis therapy using adipose tissue-derived stem cells were carried out. In clinical trials, adipose tissue-derived stem cells were intramuscularly injected into the ischemic limbs of patients with peripheral artery disease of Fontaine class III or IV who can not avoid limb amputation. Improvement of subjective symptoms and clinical findings was observed in all 4 patients who received treatment. In basic research, transplantation of adipose tissue-derived stem cells into the infarcted site of the myocardial infarction model rat revealed a reduction in infarct range and an improvement in cardiac function. From the above, it became clear that adipose tissue - derived stem cells can serve as a therapeutic source of angiogenesis therapy in place of bone marrow stem cells.

Free Research Field

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