2017 Fiscal Year Final Research Report
The role of focal discharge and reentry on atrial fibrillation
| Project/Area Number |
26461066
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
Ueda Norihiro 名古屋大学, 環境医学研究所, 助教 (10456709)
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| Co-Investigator(Renkei-kenkyūsha) |
HONJO Haruo 名古屋大学, 環境医学研究所, 准教授 (70262912)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | 心房細動 / 急性心不全 |
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| Outline of Final Research Achievements |
Inducibility of atrial fibrillation (AF) was increased by an acute stretch of atrium with the heterogeneous conduction pattern and the shortening of effective refractory period. The elevation of atrial pressure caused the shortening of effective refractory period of atrium. Conduction of atrium spread throughout all pulmonary veins. The pulmonary vein may be the key factor for AF occurrence and maintenance. Stretch activated channel and calmodulin kinase might be the targets for the therapy for AF.
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| Free Research Field |
循環器内科
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