Roles of osteoprotegerin in the development of heart failure/aortic aneurysm

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461076
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: University of Miyazaki
• Principal Investigator: Tsuruda Toshihiro 宮崎大学, 医学部, 講師 (10389570)
• Co-Investigator(Renkei-kenkyūsha): UDAGAWA Nobuyuki 松本歯科大学, 歯学部, 教授 (70245801) ; SEKIMOTO Tomohisa 宮崎大学, 医学部, 助教 (60305000)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 心不全 / 骨粗鬆症 / 加齢 / 線維化 / アポトーシス / 高血圧

Outline of Final Research Achievements

Main purpose of this study was to elucidate the possible roles for osteoprotegerin (OPG) in the development of heart failure. In 52-week-old OPG-/- mice, we found that the OPG-/- mice displayed higher blood pressure than wild-types. In addition, OPG-/- mice revealed left ventricular dilation concomitant with reduction in left ventricular contractility. In histological analysis, OPG-/- mice showed infrequent fibrosis for its heart size. Furthermore, we administered angiotensin II to 8-week-old OPG-/- mice and wild-type mice, and we found the exaggerated left ventricular hypertrophy with the impaired left ventricular contractility. Recombinant OPG to these mice partially improved the phenomena. Taken together, our results suggest that OPG may have additive effects on cardiac structure and function associated with aging and hypertension.

Free Research Field

循環器内科学