Comparison between instantaneous wave-free ratio versus morphometric assessments by intracoronary imaging

2017 Fiscal Year Final Research Report

• Project/Area Number: 26461079
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Yokohama City University
• Principal Investigator: Hibi Kiyoshi 横浜市立大学, 附属市民総合医療センター, 准教授 (20347339)
• Co-Investigator(Kenkyū-buntansha): 松下 絢介 横浜市立大学, 附属市民総合医療センター, 常勤診療医 (70727825)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: iFR / FFR / IVUS / OFDI

Outline of Final Research Achievements

Eighty lesions in 72 patients who underwent elective angiography and had intermediate lesions were enrolled. All lesions were assessed by instantaneous wave-flow ratio (iFR), fractional flow reserve (FFR), intravascular ultrasound (IVUS), optical frequency domain imaging (OFDI). iFR and FFR demonstrated moderate overall linear correlation with r value of 0.63 (p<0.001).iFR correlated significantly with both IVUS-derived minimum lumen area (MLA) (r=0.375, p=0.003) and OFDI-derived MLA (r=0.357, p=0.005). FFR also correlated significantly with both IVUS-derived MLA (r=0.472, p<0.001) and OFDI-derived MLA (r=0.445, p<0.001).

Free Research Field

coronary physiology