Comprehensive genetic analysis in patients with idiopathic ventricular fibrillation

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461087
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Keio University
• Principal Investigator: Aizawa Yoshiyasu 慶應義塾大学, 医学部(信濃町), 特任講師 (20528145)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 不整脈 / 遺伝子解析 / 心室細動 / 右脚ブロック / 次世代シークエンサー / ブルガダ症候群

Outline of Final Research Achievements

A total of 105 cases of idiopathic ventricular fibrillation were collected. There were 6 cases showing right bundle branch block. Rare variants were detected in ABCC8, CDH2, SCN3B, SCNN1B genes by the next generation sequencer. By investigating the novel genetic mutation and the mechanism of the development of ventricular fibrillation in this study, it is expected that elucidation of the pathology and tailor - made medicine for individual genotypes will be realized.

Free Research Field

循環器病学