心不全における慢性腎臓病の治療標的の探索

2015 Fiscal Year Research-status Report

• Project/Area Number: 26461088
• Research Institution: Japan Research Promotion Society for Cardiovascular Diseases
• Principal Investigator: 吉川 勉 公益財団法人日本心臓血圧研究振興会(臨床研究施設・研究部門), その他部局等, その他 (20174906)
• Co-Investigator(Kenkyū-buntansha): 香坂 俊 慶應義塾大学, 医学部, 講師 (30528659)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 心不全 / 慢性腎臓病 / バイオマーカー

Outline of Annual Research Achievements

慶應義塾大学病院、榊原記念病院、杏林大学病院に入院した急性増悪期心不全(ADHF)患者を前向きに登録した。入院中の血漿量減少が腎機能に及ぼす影響に及ぼす影響を収縮機能の低下した心不全例(rEF)と収縮機能の保たれた心不全例(pEF)で比較した。入院中の循環血漿量の低下が3分位の中で最も多い群を循環血漿量低下あり(PVR+)と判定し、それ以外を循環血漿量低下なし(PVR-)と判定した。PVR+はpEF例で腎機能悪化と関連したが、rEF例では関連しなかった。pEFおよびrEF例では、急性期利尿薬静注がPVRの予測因子となった。以上より、PVRの腎機能への影響はpEF例とrEF例で異なることが明らかとなった。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

心不全例の登録は順調に増加しつつある。本研究の課題である慢性腎臓病の臨床的意義についても上記のごとく成果を公表することができた。

Strategy for Future Research Activity

尿細管障害マーカーとの関連について未解析である。尿酸と慢性腎臓病の進展との関連についても明らかにしていない。

Causes of Carryover

バイオマーカー測定に要する費用が思ったほど使用できなかった。

Expenditure Plan for Carryover Budget

来年度は、バイオマーカー測定件数を増やすべく、研究体制を強化する。

Research Products

• [Journal Article] Extent of Late Gadolinium Enhancement on Cardiac Magnetic Resonance Images in Japanese Hypertrophic Cardiomyopathy Patients. (2016)
  • Author(s): Hen Y, Iguchi N, Utanohara Y, Takada K, Machida H, Takara A, Teraoka K, Sumiyoshi T, Takamisawa I, Takayama M, Yoshikawa T
  • Journal Title: Circ J Volume: 80 Pages: 950-957
  • DOI: 10.1253/circj.CJ-15-1100
  • Peer Reviewed / Open Access
• [Journal Article] Validation of the Get With The Guideline-Heart Failure risk score in Japanese patients and the potential improvement of its discrimination ability by the inclusion of B-type natriuretic peptide level. (2016)
  • Author(s): Shiraishi Y, Kohsaka S, Abe T, Mizuno A, Goda A, Izumi Y, Yagawa M, Akita K, Sawano M, Inohara T, Takei M, Kohno T, Higuchi S, Yamazoe M, Mahara K, Fukuda K, Yoshikawa T; West Tokyo Heart Failure Registry Investigators
  • Journal Title: Am Heart J Volume: 171 Pages: 33-39
  • DOI: 10.1136/openhrt-2015-000298.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Immunoadsorption therapy for dilated cardiomyopathy using tryptophan column-A prospective, multicenter, randomized, within-patient and parallel-group comparative study to evaluate efficacy and safety. (2016)
  • Author(s): Yoshikawa T, Baba A, Akaishi M, Wakabayashi Y, Monkawa T, Kitakaze M, Izumi T, Tomoike H
  • Journal Title: J Clin Apher Volume: － Pages: －
  • DOI: 10.1002/jca.21446.
  • Peer Reviewed / Open Access
• [Journal Article] 心不全治療薬 (2016)
  • Author(s): 吉川勉
  • Journal Title: 医薬ジャーナル Volume: 52 Pages: 426-431
• [Journal Article] Takotsubo cardiomyopathy, a new concept of cardiomyopathy: clinical feaures and pathophysiology. (2015)
  • Author(s): Yoshikawa T
  • Journal Title: Ｉｎｔ Ｊ Ｃａｒｄｉｏｌ Volume: 182 Pages: 297-303
  • DOI: 10.1016/j.ijcard.2014.12.116.
  • Peer Reviewed
• [Journal Article] Rationale and design of the double-blind, randomized, placebo-controlled multicenter trial on efficacy of early initiation of eplerenone treatment in patients with acute heart failure (EARLIER). (2015)
  • Author(s): Asakura M, Yamamoto H, Asai K, Hanatani A, Hirata K, Hirayama A, Kimura K, Kobayashi Y, Momomura S, Nakagawa Y, Nishi Y, Saito Y, Satoh Y, Yamada T, Yamashina A, Yasuda S, Yoshikawa T, Kada A, Uesaka H, Kitakaze M, on behald of the EARLIER investigators and coordinators
  • Journal Title: Cardiovasc Drugs Ther Volume: ２５ Pages: １７９－１８５
  • DOI: 10.1007/s10557-014-6565-2.
  • Peer Reviewed
• [Journal Article] Effect of estimated plasma volume reduction on renal function for acute heart failure differs between patients with preserved and reduced ejection fraction. (2015)
  • Author(s): Takei M, Shun Kohsaka S, Shiraishi Y, oda A, Izumi Y, Yagawa M, Mizuno A, Inohara T, Kohno T, Fukuda K, Yoshikawa T
  • Journal Title: Circ Heart Fail Volume: 8 Pages: 527-532
  • DOI: 10.1161/CIRCHEARTFAILURE.114.001734.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Application of the United States acute heart failure risk prediction model in Japanese patients; analysis from a contemporary multicenter registry. (2015)
  • Author(s): Makino J, Kohsaka S, Shiraishi Y, Inohara T, Goda A, Izumi Y, Yagawa M, Mizuno A, Fukuda K, Yoshikawa T
  • Journal Title: Int J Cardiol Volume: 195 Pages: 323-325
  • DOI: 10.1016/j.ijcard.2015.05.164.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Early vs. Late Reverse Ventricular Remodeling in Patients with Cardiomyopathy. (2015)
  • Author(s): Banno A, Kohsaka S, Inohara T, Koide K, Shiraishi Y, Kohno T, Sano M, Yoshikawa T, Fukuda K
  • Journal Title: J Cardiol Volume: 68 Pages: 57-63
  • DOI: 10.1016/j.jjcc.2015.07.021.
  • Peer Reviewed
• [Journal Article] MRI and serum high-sensitivity C reactive protein predict long-term mortality in non-ischaemic cardiomyopathy. (2015)
  • Author(s): Sadahiro T, Kohsaka S, Okuda S, Inohara T, Shiraishi Y, Kohno T, Yoshikawa T, Fukuda K
  • Journal Title: Open Heart Volume: 2 Pages: e000298
  • DOI: 10.1136/openhrt-2015-000298.
  • Peer Reviewed
• [Journal Article] Enhanced Oxidative Stress is Associated with Sleep-Disordered Breathing and Obesity in Patients with Heart Failure. (2015)
  • Author(s): Kondo M, Kohno T, Kohsaka S, Fukuoka R, Shiraishi Y, Sawano M, Inohara T, Sano M, Yoshikawa T, Fukuda K
  • Journal Title: Int J Cardiol Volume: 209 Pages: 133-135
  • DOI: 10.1016/j.ijcard.2016.02.042.
  • Peer Reviewed
• [Journal Article] Gender Differences in Patients with Takotsubo Cardiomyopathy: Multi-Center Registry from Tokyo CCU Network. (2015)
  • Author(s): Murakami T, Yoshikawa T, Maekawa Y, Ueda T, Isogai T, Sakata K, Nagao K, Yamamoto T, Takayama M
  • Journal Title: PLoS One Volume: 10 Pages: e0136655
  • DOI: 10.1371/journal.pone.0136655.
  • Peer Reviewed / Open Access
• [Journal Article] 理学療法の立場から (2015)
  • Author(s): 安達裕一、斎藤正和、吉川勉
  • Journal Title: Medical Alliance Volume: 1 Pages: 350-355
• [Journal Article] β遮断薬と遺伝子多型 (2015)
  • Author(s): 吉川勉
  • Journal Title: Heart View Volume: 19 Pages: 34-39
• [Presentation] Clinical Aspects of Re-hospitalized Heart Failure. A Single Center Experience with 542 Consecutive Patients Hospitalized with Acutely Decompensated Heart Failure. (2016)
  • Author(s): Yagawa Y, Makoto Suzuki M, Mahara K, Tomoike H, Shiraishi Y, Inohara T, Mizuno A, Goda A, Kohsaka S, Yoshikawa T
  • Organizer: 80th Japanese Circulation Society Meeting
  • Place of Presentation: Sendai
  • Year and Date: 2016-03-20
• [Presentation] Frequent Flyers for Acute Heart Failure: Their Outcome Compared to Patients with Single Admission or de novo Heart Failure. (2016)
  • Author(s): Akita K, Kohno T, Kohsaka S, Shiraishi Y, Yagawa Y, Higuchi S, Goda A, Mizuno A, Fukuda K, Yoshikawa T
  • Organizer: 80th Japanese Circulation Society Meeting
  • Place of Presentation: Sendai
  • Year and Date: 2016-03-19
• [Presentation] Length of Stay in Patients Hospitalized for Acute Heart Failure ―A Report from the West Tokyo Heart Failure (WET-HF) Registry―. (2016)
  • Author(s): Moriyama H, Kohno T, Kohsaka S, Shiraishi Y, Akita K, Yagawa Y, Higuchi S, Goda A, Mizuno A, Fukuda K, Yoshikawa T
  • Organizer: 80th Japanese Circulation Society Meeting
  • Place of Presentation: Sendai
  • Year and Date: 2016-03-19
• [Presentation] International Comparison of Hospitalized Patients with Heart Failure with Preserved Ejection Fraction Based on Nationwide Registry-JASPER Study. (2016)
  • Author(s): Anzai T, Nagai T, Sugano Y, Takashio S, Takahama H, Ohhara T, Kanzaki H, Noguchi T, Kusano K, Yasuda S, Saito Y, Yoshikawa T, Ogawa H
  • Organizer: 80th Japanese Circulation Society Meeting
  • Place of Presentation: Sendai
  • Year and Date: 2016-03-18
• [Presentation] Excess Plasma Volume Reduction with Diuretics More Easily Cause Worsening of Renal Function in Patients with HFPEF. (2016)
  • Author(s): Takei M, Kohsaka S, Goda A, Mizuno A, Yoshikawa T
  • Organizer: 80th Japanese Circulation Society Meeting
  • Place of Presentation: Sendai
  • Year and Date: 2016-03-18
• [Presentation] 心不全患者に対する支援活動が臨床転帰に及ぼす影響について (2015)
  • Author(s): 中山恵津子 寒川和美 辻孝子 角口亜希子 三浦稚郁子 堀健太郎 矢川真弓子 友池仁暢 吉川勉
  • Organizer: 第19回日本心不全学会
  • Place of Presentation: 大阪
  • Year and Date: 2015-10-23
• [Presentation] 急性心不全患者の短期予後予測モデルの検討：West Tokyo Heart Failure (WET-HF) Registryからの報告 (2015)
  • Author(s): 白石泰之 香坂俊 合田あゆみ 樋口聡 泉祐樹 矢川真弓子 馬原啓太郎 山添正博 水野篤 池村修寛 秋田敬太郎 澤野充明 河野隆志 福田恵一 吉川勉
  • Organizer: 第63回日本心臓病学会
  • Place of Presentation: 横浜
  • Year and Date: 2015-09-18
• [Presentation] Incidence and long-term impact of progressive hyponatremia in heart failure patients with reduced and preserved ejection fraction. (2015)
  • Author(s): Yamazoe M, Mizuno A, Kohsaka S, Shiraishi Y, Inohara T, Goda A, Izumi Y, Yagawa M, Mahara K, Yoshikawa T
  • Organizer: European Society of Cardiology
  • Place of Presentation: London
  • Year and Date: 2015-08-30
  • Int'l Joint Research
• [Presentation] Prognostic impact of the presence of atrial fibrillation in ADHF patients with preserved EF: West Tokyo Heart Failure Registry (WET-HF). (2015)
  • Author(s): Yagawa M, Izumi Y, Mahara K, Shiraishi Y, Inohara T, Goda A, Kohsaka S, Yoshikawa T
  • Organizer: 79th Japanese Circulation Society Meeting
  • Place of Presentation: Osaka
  • Year and Date: 2015-04-26
• [Presentation] Pathophysiology of heart failure with preserved ejection fraction from the point of view of nationwide registry-JASPER study. (2015)
  • Author(s): Anzai T, Nagai T, Sugano Y, Ohara T, Kanzaki H, Noguchi T, Kusano K, Yasuda S, Saito Y, Yoshikawa T, Ogawa H
  • Organizer: 79th Japanese Circulation Society Meeting
  • Place of Presentation: Osaka
  • Year and Date: 2015-04-26
• [Presentation] Patient characteristics and outcome in Japanese and British patients admitted for acute heart failure: aa prospective international cohort study. (2015)
  • Author(s): Shiraishi Y, Benjamin D, Kohsaka S, Goda A, Izumi Y, Sawano M, Inohara T, Kohno T, Tagawa M, Mahara K, Fukuda K, Yoshikawa T, Cleland JGF
  • Organizer: 79th Japanese Circulation Society Meeting
  • Place of Presentation: Osaka
  • Year and Date: 2015-04-25
• [Presentation] Impaired renal function on admission does not presdict short-term, but predicts ,long-term clinical outcomes in acutely decompensated heart failure patients. (2015)
  • Author(s): Izumi Y, Yagawa M, Mahara K, Tomoike H, Shiraishi Y, Inohara T, Goda A, Yamazoe M, Mizuno A, Kohsaka S, Yoshikawa T
  • Organizer: 79th Japanese Circulation Society Meeting
  • Place of Presentation: Osaka
  • Year and Date: 2015-04-25
• [Presentation] Difference in the impact of progressive hyponatremia on long-term mortality in heart failure patients with reduced and preserved ejection fraction. (2015)
  • Author(s): Yamazoe M, Mizuno A, Kohsa S, Inohara T, Sawano M, Kohno T, Goda A, Izumi Y, Yagawa M, Mahara K, Yoshikawa T
  • Organizer: 79th Japanese Circulation Society Meeting
  • Place of Presentation: Osaka
  • Year and Date: 2015-04-25
• [Presentation] The implication and mid-term impact of guideline-based medical therapy in elderly population admitted with heart failure. (2015)
  • Author(s): Akita K, Kohno T, Kohsaka S, Shiraishi Y, Izumi Y, Goda A, Mizuno A, Sawano M, Inohara T, Fukuda K, Yoshikawa T
  • Organizer: 79th Japanese Circulation Society Meeting
  • Place of Presentation: Osaka
  • Year and Date: 2015-04-24