2015 Fiscal Year Research-status Report
Project/Area Number |
26461088
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Research Institution | Japan Research Promotion Society for Cardiovascular Diseases |
Principal Investigator |
吉川 勉 公益財団法人日本心臓血圧研究振興会(臨床研究施設・研究部門), その他部局等, その他 (20174906)
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Co-Investigator(Kenkyū-buntansha) |
香坂 俊 慶應義塾大学, 医学部, 講師 (30528659)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Keywords | 心不全 / 慢性腎臓病 / バイオマーカー |
Outline of Annual Research Achievements |
慶應義塾大学病院、榊原記念病院、杏林大学病院に入院した急性増悪期心不全(ADHF)患者を前向きに登録した。入院中の血漿量減少が腎機能に及ぼす影響に及ぼす影響を収縮機能の低下した心不全例(rEF)と収縮機能の保たれた心不全例(pEF)で比較した。入院中の循環血漿量の低下が3分位の中で最も多い群を循環血漿量低下あり(PVR+)と判定し、それ以外を循環血漿量低下なし(PVR-)と判定した。PVR+はpEF例で腎機能悪化と関連したが、rEF例では関連しなかった。pEFおよびrEF例では、急性期利尿薬静注がPVRの予測因子となった。以上より、PVRの腎機能への影響はpEF例とrEF例で異なることが明らかとなった。
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Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
心不全例の登録は順調に増加しつつある。本研究の課題である慢性腎臓病の臨床的意義についても上記のごとく成果を公表することができた。
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Strategy for Future Research Activity |
尿細管障害マーカーとの関連について未解析である。尿酸と慢性腎臓病の進展との関連についても明らかにしていない。
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Causes of Carryover |
バイオマーカー測定に要する費用が思ったほど使用できなかった。
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Expenditure Plan for Carryover Budget |
来年度は、バイオマーカー測定件数を増やすべく、研究体制を強化する。
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[Journal Article] Extent of Late Gadolinium Enhancement on Cardiac Magnetic Resonance Images in Japanese Hypertrophic Cardiomyopathy Patients.2016
Author(s)
Hen Y, Iguchi N, Utanohara Y, Takada K, Machida H, Takara A, Teraoka K, Sumiyoshi T, Takamisawa I, Takayama M, Yoshikawa T
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Journal Title
Circ J
Volume: 80
Pages: 950-957
DOI
Peer Reviewed / Open Access
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[Journal Article] Validation of the Get With The Guideline-Heart Failure risk score in Japanese patients and the potential improvement of its discrimination ability by the inclusion of B-type natriuretic peptide level.2016
Author(s)
Shiraishi Y, Kohsaka S, Abe T, Mizuno A, Goda A, Izumi Y, Yagawa M, Akita K, Sawano M, Inohara T, Takei M, Kohno T, Higuchi S, Yamazoe M, Mahara K, Fukuda K, Yoshikawa T; West Tokyo Heart Failure Registry Investigators
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Journal Title
Am Heart J
Volume: 171
Pages: 33-39
DOI
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Immunoadsorption therapy for dilated cardiomyopathy using tryptophan column-A prospective, multicenter, randomized, within-patient and parallel-group comparative study to evaluate efficacy and safety.2016
Author(s)
Yoshikawa T, Baba A, Akaishi M, Wakabayashi Y, Monkawa T, Kitakaze M, Izumi T, Tomoike H
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Journal Title
J Clin Apher
Volume: -
Pages: -
DOI
Peer Reviewed / Open Access
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[Journal Article] Rationale and design of the double-blind, randomized, placebo-controlled multicenter trial on efficacy of early initiation of eplerenone treatment in patients with acute heart failure (EARLIER).2015
Author(s)
Asakura M, Yamamoto H, Asai K, Hanatani A, Hirata K, Hirayama A, Kimura K, Kobayashi Y, Momomura S, Nakagawa Y, Nishi Y, Saito Y, Satoh Y, Yamada T, Yamashina A, Yasuda S, Yoshikawa T, Kada A, Uesaka H, Kitakaze M, on behald of the EARLIER investigators and coordinators
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Journal Title
Cardiovasc Drugs Ther
Volume: 25
Pages: 179-185
DOI
Peer Reviewed
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[Journal Article] Effect of estimated plasma volume reduction on renal function for acute heart failure differs between patients with preserved and reduced ejection fraction.2015
Author(s)
Takei M, Shun Kohsaka S, Shiraishi Y, oda A, Izumi Y, Yagawa M, Mizuno A, Inohara T, Kohno T, Fukuda K, Yoshikawa T
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Journal Title
Circ Heart Fail
Volume: 8
Pages: 527-532
DOI
Peer Reviewed / Acknowledgement Compliant
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[Presentation] Length of Stay in Patients Hospitalized for Acute Heart Failure ―A Report from the West Tokyo Heart Failure (WET-HF) Registry―.2016
Author(s)
Moriyama H, Kohno T, Kohsaka S, Shiraishi Y, Akita K, Yagawa Y, Higuchi S, Goda A, Mizuno A, Fukuda K, Yoshikawa T
Organizer
80th Japanese Circulation Society Meeting
Place of Presentation
Sendai
Year and Date
2016-03-19
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[Presentation] International Comparison of Hospitalized Patients with Heart Failure with Preserved Ejection Fraction Based on Nationwide Registry-JASPER Study.2016
Author(s)
Anzai T, Nagai T, Sugano Y, Takashio S, Takahama H, Ohhara T, Kanzaki H, Noguchi T, Kusano K, Yasuda S, Saito Y, Yoshikawa T, Ogawa H
Organizer
80th Japanese Circulation Society Meeting
Place of Presentation
Sendai
Year and Date
2016-03-18
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[Presentation] Pathophysiology of heart failure with preserved ejection fraction from the point of view of nationwide registry-JASPER study.2015
Author(s)
Anzai T, Nagai T, Sugano Y, Ohara T, Kanzaki H, Noguchi T, Kusano K, Yasuda S, Saito Y, Yoshikawa T, Ogawa H
Organizer
79th Japanese Circulation Society Meeting
Place of Presentation
Osaka
Year and Date
2015-04-26
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[Presentation] Patient characteristics and outcome in Japanese and British patients admitted for acute heart failure: aa prospective international cohort study.2015
Author(s)
Shiraishi Y, Benjamin D, Kohsaka S, Goda A, Izumi Y, Sawano M, Inohara T, Kohno T, Tagawa M, Mahara K, Fukuda K, Yoshikawa T, Cleland JGF
Organizer
79th Japanese Circulation Society Meeting
Place of Presentation
Osaka
Year and Date
2015-04-25
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[Presentation] Impaired renal function on admission does not presdict short-term, but predicts ,long-term clinical outcomes in acutely decompensated heart failure patients.2015
Author(s)
Izumi Y, Yagawa M, Mahara K, Tomoike H, Shiraishi Y, Inohara T, Goda A, Yamazoe M, Mizuno A, Kohsaka S, Yoshikawa T
Organizer
79th Japanese Circulation Society Meeting
Place of Presentation
Osaka
Year and Date
2015-04-25
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[Presentation] Difference in the impact of progressive hyponatremia on long-term mortality in heart failure patients with reduced and preserved ejection fraction.2015
Author(s)
Yamazoe M, Mizuno A, Kohsa S, Inohara T, Sawano M, Kohno T, Goda A, Izumi Y, Yagawa M, Mahara K, Yoshikawa T
Organizer
79th Japanese Circulation Society Meeting
Place of Presentation
Osaka
Year and Date
2015-04-25
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[Presentation] The implication and mid-term impact of guideline-based medical therapy in elderly population admitted with heart failure.2015
Author(s)
Akita K, Kohno T, Kohsaka S, Shiraishi Y, Izumi Y, Goda A, Mizuno A, Sawano M, Inohara T, Fukuda K, Yoshikawa T
Organizer
79th Japanese Circulation Society Meeting
Place of Presentation
Osaka
Year and Date
2015-04-24