Assessment of the Calcification of the Nuchal Ligament and Osteophytes of the Cervical Spine in Obstructive Sleep Apnea Subjects and Snorers.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461093
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Tsurumi University
• Principal Investigator: Ando Eriko 鶴見大学, 歯学部, 助教 (30410046)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 睡眠時無呼吸症候群 / 靭帯石灰化 / レプチン

Outline of Final Research Achievements

Last year we investigated the characteristics of sleep apnea in patients from the results of their blood tests. The blood tests were performed on 39 patients (Male:25, Female:14) with sleep apnea syndrome (SAS) who were diagnosed using full-night polysomnography.
There were no morbid findings in mineral metabolism or levels of Alkaline phosphatase. These results correspond to previous studies regarding the calcification of ligaments. In a previous study, it had been reported that Leptin may be related with ligament osteosis. The level of Leptin in the male SAS patients ranged from 2.0 to 26.8 ng/ml, and from 3.8 to 34.8 ng/ml in the female SAS patients. In nine (Male:5, Female:4) of the 39 patients, the level of Leptin indicated an abnormal value, over 13.0 ng/ml in the males, and over 21.8 ng/ml in the females. In addition, there were significant positive correlations between the level of Leptin and obesity (Body mass index: BMI), and SAS severity (Apnea-hypoapnea index: AHI).

Free Research Field

睡眠時無呼吸症候群