Prediction of Cardiovascular Events in Patients with Atrial Fibrillation: Contribution of Echocardiography

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461096
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Kansai Medical University
• Principal Investigator: MIYASAKA yoko 関西医科大学, 医学部, 講師 (10343675)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 心房細動 / 心エコー図 / 心血管イベント / 予測因子

Outline of Final Research Achievements

Left atrial (LA) enlargement has been proposed as a barometer of diastolic dysfunction and a predictor of congestive heart failure (CHF) in patients with sinus rhythm. Whether LA volume predicts CHF in patients with atrial fibrillation (AF) is not well known.To determine the clinical importance of LA volume in the prediction of CHF in patients with AF, AF patients referred for clinically-indicated echocardiogram, without a history of significant mitral valve disease, congenital heart disease, pacemaker, or cardiac surgery were included and followed forward them. Of 456 AF patients (mean 70 ± 10 year-old, 67% men), 46 (10%) developed CHF events during a mean follow-up of 44 ± 31 months. In a multivariate Cox proportional hazards model, greater indexed LA volume (HR 1.2, 95% CI 1.1-1.3, P<0.01) was independent of age (HR 1.04, 95% CI 1.01-1.07, P=0.03), sex, history of CHF, hypertension, diabetes, and LV ejection fraction for the prediction of CHF development.

Free Research Field

循環器内科