Clinical impact of infiltration adn maturation of dendritic cells in patients with dilated cardiomyopathy

2017 Fiscal Year Final Research Report

• Project/Area Number: 26461098
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: Sugano Yasuo 国立研究開発法人国立循環器病研究センター, 病院, 医長 (00317124)
• Co-Investigator(Kenkyū-buntansha): 安斉 俊久 北海道大学, 医学研究院, 教授 (60232089)
• Co-Investigator(Renkei-kenkyūsha): OUGOU Keiko 国立研究開発法人国立循環器病研究センター, 病院, 医師 (30601827)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 拡張型心筋症 / 心不全 / 炎症 / 線維化 / リモデリング

Outline of Final Research Achievements

Biopsy samples from 182 DCM patients were immunohistochemically stained with antibodies to infiltrating cells. Median numbers of myocardial CD3, CD68 and CD163-cell infiltrates were 8.1/mm2, 22.3/mm2, 6.5/mm2, respectively. Patients with higher counts of infiltrating CD3-, CD68- and CD163-positive cells had significantly poorer outcomes (p=0.007, p=0.011 and p=0.022, respectively). A high CD163-positive infiltrate count was independently associated with worse outcome in multivariate Cox regression analysis (hazard ratio=1.77, p=0.004), and multivariate linear regression analysis revealed that the CD163 cell count was an independent determinant of CAF (p<0.001).
DCM with increased myocardial immune activation was associated with poor long-term outcome. The association between M2 macrophages and collagen formation suggests the phenotypic polarisation of macrophages toward M2 may be associated with ventricular remodeling in DCM.

Free Research Field

循環器内科