Prediction for estimating the degree of damaged pulmonary vascular bed using blood biomarkers

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461106
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Nagoya University
• Principal Investigator: Kondo Takahisa 名古屋大学, 医学系研究科, 寄附講座教授 (00303644)
• Research Collaborator: SHIMAZU Shuzo 名古屋大学, 大学院医学系研究科・循環器内科学, 大学院生 ; NAKANO Yoshihisa 名古屋大学, 大学院医学系研究科・循環器内科学, 研究生 ; KAMIMURA Yoshihiro 名古屋大学, 大学院医学系研究科・循環器内科学, 大学院生 ; SHIMOKATA Shigetake 名古屋大学, 大学院医学系研究科・循環器内科学, 大学院生
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 肺高血圧症

Outline of Final Research Achievements

Presence of pericardial effusion, an average mean right atrial pressure of >=10mmHg, or cardiac index <2.5 L/min/m2 were associated with mortality among 81 consecutive patients diagnosed with group 1 or 1′ PH,. Left ventricular (LV) end-systolic volume index was significantly associated with mortality among 31 non-ischemic dilated cardiomyopathy (DCM) patients with PH (Group 2). The peak PETCO2 obtained by cardiopulmonary exercise testing (CPX) could provide useful prognostic markers for 12 patients with CTEPH (Group 4), but not 17 group 1 PH patients treatment with bosentan therapy. The peak PETCO2 may become a marker for estimating the degree of restored pulmonary vascular bed in group 4 PH (CTEPH).
In some PH patients, serum vascular endothelial growth factor (VEGF)165b, an inhibitory VEGF splice variant, was elevated. Study to investigate the relationship between VEGF165b and mean pulmonary arterial pressure, pulmonary vascular resistance, or cardiac index is underway.

Free Research Field

循環器内科学