Evaluation of prognostic factors and efficacy of early treatment for borderline pulmonary arterial hypertension

2017 Fiscal Year Final Research Report

• Project/Area Number: 26461107
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Mie University
• Principal Investigator: Yamada Norikazu 三重大学, 医学系研究科, リサーチアソシエイト (60303731)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 肺高血圧症 / 早期治療介入 / 運動負荷 / 薬物治療

Outline of Final Research Achievements

To eluciate the efficacy and safety the eraly pharmacological intervention for the borderline pulmonary arterial hypertension associated with connective tissue disease, we examined the hemodynamic parameters in pre- and follow-up period under exercise with right heart catheterization between treatment group and non-treatment group. Progression of abnormal response in exercise was observed in non-treatment group but not in treatment group. In conclusion, early pharmacological intervention might be safe and effective for patients with borderline pulmonary arterial hypertension to prevent pulmonary vascular remodeling.

Free Research Field

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