RIsk evaluation of trans fatty acids in atherosclerosis in Japan

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461109
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Kobe University
• Principal Investigator: Shinke Toshiro 神戸大学, 医学部附属病院, 准教授 (60379419)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: トランス脂肪酸 / 冠動脈疾患 / 脂質異常症 / 栄養学 / 内科 / 動脈硬化

Outline of Final Research Achievements

Recent epidemiological studies showed that excessive intake of trans fatty acids (TFA) can be a residual risk for the development of coronary artery disease (CAD) even under medical management. We aimed to investigate the association between serum TFA concentration and CAD in Japan.
Serum TFA level was elevated in young patients with CAD, particularly in patients with thin-cap fibroatheroma. Multivariate logistic regression analysis identified TFA level as an independent risk factor for future cardiovascular events. Animal studies have indicated that TFA increases systemic inflammation and oxidative stress.
In conclusion, TFA may affect onset and vulnerability of coronary plaque. Serum TFA concentration may represent another cardiovascular risk factor during conventional risk factor management.

Free Research Field

循環器内科学