2016 Fiscal Year Final Research Report
Role of ROCK in diabetes-mediated cardiovascular disease: from bench to bedside
| Project/Area Number |
26461110
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Hiroshima University |
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Principal Investigator |
NOMA KENSUKE 広島大学, 原爆放射線医科学研究所, 助教 (00379893)
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| Research Collaborator |
Liao James K. シカゴ大学, メディカルセンター 循環器科, 教授
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | ROCK / 糖尿病 / 血管内皮機能 / 心血管障害 |
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| Outline of Final Research Achievements |
From the rsults in endothelial cell and animal studies, we have found that high glucose inhibited endothelial function, and activated ROCK activity and ROS generation, all of which were reversed by adminstration of ROCK inhibitor. From the result in clinical study, ROCK activity was increased in diabetes patients compared to non-diabetes subjects. These results indicate not only that ROCK could be a therapeutic target in diabets-evoked cardiovascular disease, but also that ROCK activity could be an useful biomarker of cardiovascular outcome in such patients.
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| Free Research Field |
医歯薬学 循環器内科学
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