Usefulness of plasma thrombin-cleaved osteopontin (N-half OPN) level on diagnosis of thrombotic disease

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461112
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Ehime University
• Principal Investigator: Higaki Jitsuo 愛媛大学, 医学系研究科, 教授 (70189744)
• Co-Investigator(Renkei-kenkyūsha): Miyoshi Kenichi 愛媛大学, 大学院医学系研究科, 講師 (50423439) ; Irita Jun 愛媛大学, 医学部附属病院, 講師 (00423442) ; Nagao Tomoaki 愛媛大学, 医学部附属病院, 医員 (20512164)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: オステオポンチン / アテローム血栓性脳梗塞

Outline of Final Research Achievements

We investigated whether thrombin-cleaved osteopontin (N-half OPN) is useful as a biomarker of acute atherothrombotic stroke. They were divided into the atherothrombotic and non-atherothrombotic groups. N-half OPN, MMP-9 were measured at admission. After excluding patients who met the exclusion criteria, 60 of the 100 patients enrolled in this study. The ischemic stroke subtypes were atherothrombotic (n=28.4%), cardioembolic (n=19.3%) and lacunar (n=13.2%). N-half OPN and MMP-9 levels were significantly higher in the atherothrombotic than in the non-atherothrombotic group. After adjustment for the prevalence of hypertension, diabetes and dyslipidemia, N-half OPN levels of 5.47 pmol/l and MMP-9 levels of >605.5 ng/ml were identified as independent predictors of atherothrombosis. Within 3 hours from stroke onset, only N-half OPN independently predicted atherothrombotic stroke, suggesting usefulness of N-half OPN for diagnosis of the early evaluation of ischemic stroke.

Free Research Field

高血圧