2017 Fiscal Year Final Research Report
Exploratory study of novel oxidative stress markers for early diagnosis of pulmonary hypertension
Project/Area Number |
26461113
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Cardiovascular medicine
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Research Institution | Nagasaki University |
Principal Investigator |
IKEDA Satoshi 長崎大学, 医歯薬学総合研究科(医学系), 講師 (10336159)
|
Co-Investigator(Kenkyū-buntansha) |
浦田 芳重 長崎大学, 医歯薬学総合研究科(医学系), 助教 (30185087)
前村 浩二 長崎大学, 医歯薬学総合研究科(医学系), 教授 (90282649)
|
Project Period (FY) |
2014-04-01 – 2018-03-31
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Keywords | 肺高血圧症 / 酸化ストレス |
Outline of Final Research Achievements |
The prognosis of pulmonary arterial hypertension (PAH) is poor; therefore, early diagnosis and treatment is required. However, the useful biomarkers for the diagnosis have not been established. In the present study, we examined whether oxidative stress-related proteins, such as glutathionylated protein and PGC-1α, could be the biomarkers, because oxidative stress is involved in PAH development and progression. As a result, the expression of the two proteins did not differ between PAH model and control animal. We concluded that these proteins were not good biomarkers for the diagnosis of PAH.
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Free Research Field |
循環器内科学
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