2016 Fiscal Year Final Research Report
Development of the role of midkine on the cardio-renal association
| Project/Area Number |
26461121
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Cardiovascular medicine
|
|---|
| Research Institution | Yamagata University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | ミッドカイン / 心肥大 / 腎不全 |
|---|
| Outline of Final Research Achievements |
It has knwon that cardiac remodeling is observed during chronic kideny disease. We found that levels of midkine in the kidney and serum has beed increased before remodeling occured. Circulating midkne modulates intracellular signaling through GPCR, and induces cardiac hypertrophy, including increased ANP expressions.
|
| Free Research Field |
循環器内科学
|
