2017 Fiscal Year Final Research Report
The role of HMGB1 in regulating mitochondrial dysfunction induced by aging
| Project/Area Number |
26461122
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Cardiovascular medicine
|
|---|
| Research Institution | Yamagata University |
|---|
Principal Investigator |
KUBOTA Isao 山形大学, 学内共同利用施設等, 理事 (30161673)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
宍戸 哲郎 山形大学, 医学部, 助教 (60400545)
|
|---|
| Project Period (FY) |
2014-04-01 – 2018-03-31
|
| Keywords | 糖尿病 / 脂質異常症 / 老化 |
|---|
| Outline of Final Research Achievements |
It is well documented that reperfusion by PCI is the most effective therapy for acute myocardial infarction. Although several factors including aging and metabolic disorders is known to be associated with their prognosis, precise mechanism has not been clearly determined. We found that agingn and metabolic disorder lowered expression levels of SMP30, and ischemia/reperfusion injury was worsened at the resullt of decreased expression of SMP30. Moreover preseavation of SMP30 expression attenuated ischemia/reperfusion injury.
|
| Free Research Field |
循環器内科
|
