The effect of high-fat low-carbon diet on cardiac function and metabolism

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461124
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: The University of Tokyo
• Principal Investigator: Toko Haruhiro 東京大学, 医学部附属病院, 特任助教 (40436358)
• Research Collaborator: HARADA Mutsuo ; KO Toshiyuki ; MURAKAMI Haruka ; ISHIZUKA Masato
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 高脂肪低炭水化物食 / 心肥大 / 心不全

Outline of Final Research Achievements

In a failing heart, a workload of each cardiomyocyte is increased to recover cardiac function. Although the increase requires more energy, failing cardiac cells are reported not to product enough energy. High fat diet is reported to reactivate lipid metabolism and increase energy product. So, we examined whether high fat low carbon (HFLC) diet could preserve cardiac function in murine failing models via an increase of energy production.
Our results showed that HFLC did not increase energy production, but HFLC decreased cardiac hypertrophy in a pressure-overload model and preserved cardiac function in a dilated cardiomyocyte model. We are studying mechanisms of how HFLC keeps cardiac function under pathological conditions.

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