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2016 Fiscal Year Final Research Report

Role of mitochondrial permeability transition in necroptosis of the cardiomyocyte

Research Project

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Project/Area Number 26461133
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionSapporo Medical University

Principal Investigator

Miura Tetsuji  札幌医科大学, 医学部, 教授 (90199951)

Project Period (FY) 2014-04-01 – 2017-03-31
Keywordsmitochondria / cell death / necroptosis / autophagy / signal transduction
Outline of Final Research Achievements

This study showed that, in contrast to its role in necrosis, mitochondrial permeability transition (MPT) does not directly trigger cell death in necroptosis of cardiomyocytes and that necroptotic signals significantly inhibit autophagy, which is potentially modulated by MPT, leading to exaggeration of necroptotic cardiomyocyte death. Sequestration of p62 from p62-LC3-II interaction by increased p62-RIP1 interaction and inhibition of fusion of autophagosomes with lysosomes were proposed to be mechanisms by which necroptotic signals inhibits autophagy.

Free Research Field

循環器病学

URL: 

Published: 2018-03-22  

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