The role of omentin in the vascualr disease

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461143
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Nagoya University
• Principal Investigator: Shibata Rei 名古屋大学, 医学系研究科, 寄附講座准教授 (70343689)
• Co-Investigator(Renkei-kenkyūsha): MUROHARA TOYOAKI 名古屋大学, 大学院医学系研究科, 教授 (90299503)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: オメンチン / 動脈硬化 / 血管リモデリング

Outline of Final Research Achievements

Adipose tissue functions as an endocrine organ by secreting adipokines that can directly affect nearby or remote organs. Omentin is an adipokine whose concentration is down-regulated in subjects with obesity-related disorders. Low levels of circulating omentin appear to associate with the increased prevalence of obesity-linked vascular diseases including atherosclerosis. In our study, we have shown that omentin exerts beneficial effects on the vascular disease by directly acting on the component cells in the blood vessel. The therapeutic approaches aimed at increasing circulating omentin levels could be valuable for prevention or treatment of cardiovascular diseases.

Free Research Field

循環機内科学