Elucidation of mechiansms underlying Nox4-mediated enhancement of hypoxic responses in endothelial cells

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461145
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Kyushu University
• Principal Investigator: Ago Tetsuro 九州大学, 大学病院, 講師 (30514202)
• Research Collaborator: KITAZONO TAKANARI 九州大学, 大学院・医学研究院・病態機能内科学, 教授 (70284487) ; KURODA JUNNYA 九州大学, 大学病院・腎高血圧脳血管内科, 助教 (70614858) ; WAKISAKI YOSHINOBU 九州大学, 大学病院・腎高血圧脳血管内科, 助教 (50631694) ; TACHIBANA MASAKI 九州大学, 大学院・医学研究院・病態機能内科学, 大学院生 ; YOSHIKAWA YOJI 九州大学, 大学院・医学研究院・病態機能内科学, 大学院生 ; KOMORI MOTOHIRO 九州大学, 大学院・医学研究院・病態機能内科学, 大学院生 ; MAKIHARA NORIKO 九州大学, 大学院・医学研究院・病態機能内科学, 大学院生 ; NISHIMURA ATARU 九州大学, 大学院・医学研究院・病態機能内科学, 大学院生 ; NAKAMURA KUNIYUKI 九州大学, 大学院・医学研究院・病態機能内科学 ; SADOSHIMA JUNICHI Rutgers New Jersey Medical School, Department of Cell Biology and Molecular Medicine, Professor
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: NADPH oxidase / 活性酸素種 / 内皮細胞 / 周皮細胞 / 低酸素 / 脳梗塞 / 動脈硬化 / 下肢虚血

Outline of Final Research Achievements

Stroke, myocardial infarction, and arteriosclerosis obliterans are representative adult vascular diseases to be overcome. Although there are many sizes of vascular vessels, endothelial cells cover intraluminal sides of any vascular vessels. Because there is abundant molecular oxygen within the arteries, reactive oxygen species (ROS) can be easily produced in endothelial cells and be associated with the development and progression of the vascular diseases. Thus, it is indispensable for overcoming of the vascular diseases to understand well the mechanisms by which ROS are produced and regulated in endothelial cells. In the present study, I elucidate ischemic/hypoxic responses and pathological roles mediated by ROS-producing Nox4 in endothelial cells.

Free Research Field

脳卒中学，血管病学，分子細胞生物学