Effect of iron deficiency on animal model of pulmonary emphysema

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461177
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Yamagata University
• Principal Investigator: SHIBATA Yoko 山形大学, 医学部, 講師 (60333978)
• Co-Investigator(Renkei-kenkyūsha): KUROTANI Reiko 山形大学, 大学院理工学研究科, 准教授 (00453043) ; ABE Shuichi 山形大学, 医学部, 非常勤講師 (40400543) ; INOUE Sumito 山形大学, 医学部, 助教 (70466621)
• Research Collaborator: SATO Masamichi ; SATO Kento
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 慢性閉塞性肺疾患 / 肺気腫 / 鉄 / たばこ

Outline of Final Research Achievements

Serum iron is reportedly related to smoking tolerance. It is also known that low serum iron levels are associated with rapid decline in respiratory function due to smoking. In this study, we investigated the mechanism why low level of serum iron leads to a decline in respiratory function in the smoke-exposed mouse emphysema model. After administering an iron deficient diet to mice, smoking exposure was carried out on the mice for two weeks using a smoking exposure apparatus. In bronchoalveolar lavage analysis, significant accumulation of alveolar macrophages was observed in the iron deficient food intake group as compared with the normal food ingestion group. Next, after the mice in both groups were exposed to smoking for 8 weeks, respiratory function tests and pathological examinations were performed to evaluate emphysema formation. Emphysema formation progressed in the iron deficient diet group compared to the normal diet group.

Free Research Field

呼吸器内科学