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2016 Fiscal Year Final Research Report

Investigation of asbestos-induced carcinogenesis via actin-binding protein, p116Rip.

Research Project

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Project/Area Number 26461180
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionGunma University

Principal Investigator

YASUHIKO KOGA  群馬大学, 大学院医学系研究科, 助教 (10533862)

Co-Investigator(Renkei-kenkyūsha) KAIRA KYOUICHI  群馬大学, 医学部, 教授 (40400783)
DOBASHI KUNIO  群馬大学, 保健学科, 教授 (00241894)
Project Period (FY) 2014-04-01 – 2017-03-31
Keywords非閉塞性肺疾患 / 肺線維症 / 呼吸器感染症
Outline of Final Research Achievements

It has been reported that p116Rip has an ability to interact with cytoskeletal molecules such as myosin, actin, and myosin phosphatase, suggesting that p116Rip affects cell motility. However, the role of p116Rip has not been investigated well. In this study, we focused on the actin which binding to asbestos in vitro and on the role of p116Rip interacting with actin. We investigated the localization of p116Rip in lung tissues in patients with asbestos exposure and clarified the co-localization of p116Rip with EMT markers such as vimentin, β-catenin, and α-smooth muscle actin. The results suggested that p116Rip has an interaction with EMT markers and plays a role of asbestos-induced carcinogenesis.

Free Research Field

医歯薬学

URL: 

Published: 2018-03-22  

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