2016 Fiscal Year Final Research Report
Molecular mechanisms in the pathogenesis of acute lung injury
| Project/Area Number |
26461190
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Yamaguchi University |
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Principal Investigator |
HASEGAWA Akihiro 山口大学, 医学(系)研究科(研究院), 准教授 (80376376)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAYAMA Toshinori 千葉大学, 大学院医学研究院, 教授 (50237468)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 肺炎 / 好中球 / 炎症 |
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| Outline of Final Research Achievements |
We developed a color-coded real-time imaging model of cell migration into the lung in a mouse model of acute lung injury, and identify the cellular process required for the initiation of the acute lung injury phenotype. Accumulation of inflammatory cells in the lung was quantitatively imaged. Effect of in vivo treatment with monoclonal antibody was examined in order to explore the potential therapeutic target for acute lung injury.
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| Free Research Field |
医歯薬学
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