• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2016 Fiscal Year Final Research Report

Elucidation of the role of IL-23 in bronchial asthma caused by skin barrier dysfunction and drug discovery application

Research Project

  • PDF
Project/Area Number 26461198
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionKeio University

Principal Investigator

Kagawa Shizuko  慶應義塾大学, 医学部(信濃町), 研究員 (80645507)

Co-Investigator(Renkei-kenkyūsha) Fukunaga Koichi  慶應義塾大学, 医学部, 専任講師 (60327517)
Suzuki Yusuke  慶應義塾大学, 医学部, 特任講師 (80306696)
Kubo Akiharu  慶應義塾大学, 医学部, 専任講師 (70335256)
Research Collaborator Kabata Hiroki  
Masaki Katsunori  
Mochimaru Takao  
Matsusaka Masako  
Project Period (FY) 2014-04-01 – 2017-03-31
Keywords経皮感作 / 皮膚バリア / IL-23
Outline of Final Research Achievements

Th17 cells are the main cells that produce IL-17A.We found that IL-23 is required for the differentiation of Th17 cells via a patch application on the skin.In oder to find a therapeutic target of percutaneous sensitized asthma, I focused on the role of IL-23 produced in the local skin region and the role of Th17 in cytokine enhancement by administrating anti-IL-23 or control IgG to a percutaneously sensitized asthma mouse model, and then evaluating it for eosinophilic airway inflammation In the group to which the anti-IL-23 antibody was administered during the sensitization phase, the production of OVA-specific IgG1 antibody tended to decrease compared to the group to which the control IgG antibody was administered, and furthermore, the bronchoalveolar lavage fluid eosinophil count and eosinophil infiltration in tissues were found to decrease significantly.

Free Research Field

皮膚科学

URL: 

Published: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi