Analysis of the cyst progress associated with hypertension in in ADPKD

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461207
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Hokkaido University
• Principal Investigator: Nishio Saori 北海道大学, 大学病院, 講師 (90463736)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 多発性嚢胞腎 / 腎内RAS / 高血圧

Outline of Final Research Achievements

Hypertension is a well-recognized complication of autosomal dominant polycystic kidney disease (ADPKD). Hypertension relates to progressive kidney enlargement and is significant independent risk factor for progression to end-stage renal disease.　However, the definite mechanisms leading to hypertension in ADPKD are not well understood. The purpose of this study is to examine the effects of antihypertensive drugs for pkd1 conditional knockout mice, and the participation of intrarenal RAS in ADPKD. We generated the pkd1 conditional knockout mice (Pkd1 KO mice). To evaluate the effects of antihypertensive drugs, Pkd1 KO mice were treated by amlodipine or olmesartan or aliskiren, or vehicle for 12 weeks. Aliskiren treatment significantly reduced renal cystic index. Aliskiren treatment group improved tubulointerstital fibrosis. Renin, Ang II and AGT expression were increased significantly in cystic kidneys. Aliskiren prevented intrarenal RAS activation and cystic progression.

Free Research Field

腎臓内科学