2016 Fiscal Year Final Research Report
Management of acute kidney injury in consideration of site specificity of renal tubule through the regulation of glucose metabolism
| Project/Area Number |
26461208
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 虚血再灌流 |
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| Outline of Final Research Achievements |
These potential therapeutic opportunities utilizing RNAi in vivo are just now being recognized injected from vein, however, the effects of RNAi in vivo injected from renal artery is not well known. It is useful clinically to deliver the vector locally through trans-aortic cathether to reduce adverse effect of siRNA theraphy.Therefore, we chose inhibition of p53 expression following ischemia-reperfusion injury(IR) injected from renal artery as a means to test the efficacy of siRNA in vivo in reducing tubular cell injury and improving renal function.
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| Free Research Field |
腎臓病学
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