2016 Fiscal Year Final Research Report
Vicious cycle toward glomerulosclerosis
| Project/Area Number |
26461210
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
|---|
| Research Field |
Kidney internal medicine
|
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| Research Institution | University of Tsukuba |
|---|
Principal Investigator |
Nagata Michio 筑波大学, 医学医療系, 教授 (10192238)
|
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | ポドサイト / 糸球体硬化 |
|---|
| Outline of Final Research Achievements |
Podocyte specific CD25 expression mice causes glomerular injury by inje3ction of its ligand immunotoxin. We found that podocyte loss caused intracapillary PAI-1 up-regulation from endothelial cells that subsequently bound with uPA leading to beta-1 integrain endocytosis. In addition endothelial adhesion molecules up-regulation is accompanied by lipid peroxidation and foam cell formation. All together may be responsible for focal segmental gloemrulosclerosis.
|
| Free Research Field |
腎臓学
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