2016 Fiscal Year Final Research Report
The role of CTGF in anti-glomerular basement membrane glomerulonephritis
| Project/Area Number |
26461225
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
YOKOI HIDEKI 京都大学, 医学研究科, 講師 (90378779)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 糸球体腎炎 / 増殖因子 / 腎不全 / タンパク尿 / ノックアウトマウス |
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| Outline of Final Research Achievements |
In this study, we induced anti-GBM glomerulonephritis in podocyte-specific CTGF knockout mice.These mice exhibited no improvement of proteinuria, crescentic formation, mesangial expansion and macrophage infiltration.
Therefore, we generated mesangial cell-CTGF knockout mice (Mes-CTGF cKO mice) using PDGFR-alpha-Cre mice. Mes-CTGF cKO mice showed reduction of crescentic formation, mesangial expansion, proteinuria, TGF-beta1, alpha-SMA, fibronectin and MCP1 expression. Infiltration of macrophages was also inhibited and the ratio of M1 macrophage/M2 macrophage was significantly reduced.
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| Free Research Field |
腎臓内科学
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