2017 Fiscal Year Final Research Report
Development of next generation kidney disease biomarker and therapy using microRNA in exosome
| Project/Area Number |
26461231
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kochi University |
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Principal Investigator |
Horino Taro 高知大学, 教育研究部医療学系臨床医学部門, 講師 (90448382)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | microRNA / エクソソーム / ループス腎炎 / IgA腎症 |
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| Outline of Final Research Achievements |
Biomarker candidate miRNA was identified from kidney tissue of lupus nephritis model and patients with lupus nephritis or IgA nephropathy.
We clarified that miR-26a is involved in podocyte disorder via expression of Podocin and Synaptopodin with respect to miR-26a, and urinary miR-26a excretion becomes significantly high in lupus nephritis and is useful as a diagnostic biomarker.
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| Free Research Field |
腎臓
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