2016 Fiscal Year Final Research Report
The role of nitric oxide derived from xanthine oxidoreductase in renal vascular system
| Project/Area Number |
26461232
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Research Collaborator |
HAGA Yoshie
MURAKAMI Noboru
KANSUI Yasuo
GOTO Kenichi
MATSUMURA Kiyoshi
NOGUCHI Hideko
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 虚血再灌流障害 / 活性酸素 / キサンチンオキシドリダクターゼ / 血管 |
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| Outline of Final Research Achievements |
Study using XOR gene disrupted mice. 1) Renal ischemia reperfusion induced severe renal damage in XOR+/+ mice compared to XOR+/- mice. ROS generated by XOR increased the expression of inflammation related genes and induced the damage to the cortical region in kidney. 2) Administration of nitrite before ischemia protected renal tissue from ischemia reperfusion injury. 3) Hypoxia/reoxygenation induced the expression of XOR mRNA in human endothelial cells. 4) Administration of LNAME increased the systolic blood pressure in XOR+/- mice compared to XOR+/+ mice and induced vascular dilatation and degeneration of the media at thoracic aorta wall in XOR+/- mice. 5) The deletion of both XOR and eNOS gene showed significant decrease in life span.
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| Free Research Field |
高血圧・血管
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