Mechanisms to develop renal cyst formation and progression by disruption of cilia/centriole and cell cycle relationships

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461235
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: yokoyama Takahiko 京都府立医科大学, 医学(系)研究科(研究院), 教授 (70191525)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 腎嚢胞 / 細胞増殖 / 細胞周期 / 繊毛

Outline of Final Research Achievements

Renal cysts occur when kidney tubules become enlarged. These cysts are observed in numerous genetic deceases and, recently, several causative genes for these deceases have been cloned. Most of the products of these genes are localized in cilia and/or centrioles. In addition, mutant mice lacking cilia develop renal cysts. Therefore, cilia are thought to have an important role in renal cystogenesis.
Ne of the mechanisms to develop renal cysts is abnormal cell proliferation. Presence of cilium is tightly linked with cell cycle. In the present study, we studied relationships among cell cycle, cell proliferation and renal cyst development in detail.

Free Research Field

発生生物学