2016 Fiscal Year Final Research Report
Clarification of the role of CX3CR1/FKN/AIM axis in IgA nephrology
| Project/Area Number |
26461237
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Research Collaborator |
ARAI Satoko
MIYAZAKI Toru
TAKAHATA Akiko
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | IgA腎症 / AIM / マクロファージ / 起炎性 / gddY |
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| Outline of Final Research Achievements |
Recent papers revealed that apoptosis inhibitor of macrophage (AIM; also called CD5L), plays important roles in arthrosclerosis, obesity-associated autoimmunity, and clearance in hepatocellular carcinoma. Furthermore, the most recent investigated features are that AIM is involved in renal tissue repair, and pathology of acute kidney injury [AKI]. In this study, we found that AIM contributes to the phlogogenesity of IgAN.
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| Free Research Field |
腎臓内科
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