2016 Fiscal Year Final Research Report
Significance of Klotho as a target molecule for CKD progression, severe process and early intervention
| Project/Area Number |
26461243
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
TSUCHIYA KEN 東京女子医科大学, 医学部, 教授 (00246472)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 慢性腎臓病 / Klotho / リン / 線維化 |
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| Outline of Final Research Achievements |
It is estimated that fibrosis in renal tubules / interstitia is important for progression and severity of chronic kidney disease (CKD) irrespective of the causative disease. Conventionally, in renal impairment, a protein restricted diet is indicated, but it is presumed that the phosphorus component of this protein acts in tissue disorder. Klotho protein that regulates this phosphorus was discovered, and the decline in its work further exacerbates renal impairment, suggesting the possibility of being treated in the future.
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| Free Research Field |
腎臓内科
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