2017 Fiscal Year Final Research Report
Effects of planar cell polarity and cytoskeleton in NPHP cystic kidney development
| Project/Area Number |
26461245
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
津田 雅之 高知大学, 教育研究部医療学系基礎医学部門, 准教授 (90406182)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | 嚢胞腎 / ネフロン癆 |
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| Outline of Final Research Achievements |
Analysis of intracellular localization of planar cell polarity factor and cytoskeletal regulator as a candidate factor causing renal tubular expansion in cystic kidneys resulted in no change in localization of the factor. It was inferred that there was no involvement of plane cell polarity and cytoskeleton in renal tubular expansion.
In addition, as a result of development of a method for establishing a renal tubular epithelial cell line from cystic kidney, we succeeded in establishing a cell line from renal tubular epithelial cells before renal tubular expansion in inv_deltaC kidneys.
In addition, point mutant mice were prepared for functional analysis of Inv.
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| Free Research Field |
腎臓内科
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