2017 Fiscal Year Final Research Report
Pulse waveform analysis of bidirectional aortic blood flow: Pathophysiological implications for target organ damage in hypertension
Project/Area Number |
26461248
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Kidney internal medicine
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Research Institution | Miyagi University of Education (2016-2017) Tohoku University (2014-2015) |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2018-03-31
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Keywords | 高血圧 / 大動脈 / 血流 / 臓器障害 / 腎機能 / 血行動態 / 動脈硬化 / 臨床病態学 |
Outline of Final Research Achievements |
This study investigated the pathogenic influence of aortic pulsatile flow on hypertensive target organ damage. Bidirectional pulse waveform of aortic flow velocity was noninvasively recorded in hypertensive patients to calculate the ratio of the early diastolic reverse velocity to the systolic forward velocity (the reverse flow ratio) and the aortic compliance. The aortic flow reversal was inversely associated with the estimated glomerular filtration rate, indicating its contribution to renal dysfunction caused by aortic stiffening. Also, the aortic compliance was associated with the aortic pressure decay during diastole and the subendocardial variability index, suggesting that decreased aortic compliance predisposes to myocardial ischemia. These results indicate that target organ damage in hypertension is potentially attributable to aortic stiffening-induced flow abnormalities.
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Free Research Field |
循環器内科学、腎臓内科学
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