Epigenetical regulation in cardiorenal syndrome by sympathetic nerve activity

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461249
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: The University of Tokyo
• Principal Investigator: Shimosawa Tatsuo 東京大学, 医学部附属病院, 講師 (90231365)
• Co-Investigator(Renkei-kenkyūsha): OGURA Sayoko 日本大学, 医学部, 助教 (30618202)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 心腎連関 / カルシウムチャンネル / 交感神経 / 拡張機能障害

Outline of Final Research Achievements

Using chronic kidney disease (CKD) model rat, we clarified renal sympathetic nerve is important in regulating cardiac calcium channel, SERCA, and controlling cardiac diastolic function. Our CKD model is uni-nephrectomized and high salt loaded rat and it developed diastolic dysfunction along with renal dysfunction. When renal sympathetic nerve is cut, cardiac dysfunction was recovered independent from blood pressure and renal function. mRNA expression of SERCA was also recovered by mechanical sympathectomy. Our preliminary study indicated that afferent sympathetic nerve is essential in this recover of cardiac function.　In addition, prostaglandin E from kidney may modulate cardiac function.

Free Research Field

腎臓