2017 Fiscal Year Final Research Report
Elucidation the mechanism of progression on peritoneal sclerosis in peritoneal dialysis
| Project/Area Number |
26461252
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Okayama University |
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Principal Investigator |
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| Research Collaborator |
TSUJI KENZI
TORII AKIKO
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | 腹膜中皮細胞 / 腹膜透析 / 細胞療法 |
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| Outline of Final Research Achievements |
In Vitro study, peritoneal mesothelial cells were performed the morphological and qualitative evaluation. The cells used were peritoneal mesothelial cells, with cobblestone morphologic cells (Epi cells) and fibroblast-like peritoneal mesothelial cells (Fib cells). From the result, it is suggested that Fib cells play an important role in peritoneal sclerosis although Epi cells change poorly not only in acidic stimulation but also in sugar stimulation.
In vivo study, Epi cell supernatant significantly improved peritoneal damage and peritoneal adhesion compared to the peritoneal sclerosis positive model, however in Fib cell supernatants, peritoneal deterioration were significantly observed. From these results, it is suggested that secreted factor from peritoneal mesothelial cells is also important. We will also conduct exosome analysis in secreted factors to aim for elucidation of its mechanism.
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| Free Research Field |
腎臓内科、透析学、再生医療
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