Elucidation and Expansion of Molecular Physiology of Salt Sensitivity and Hypertensin Based on Tubular Mechanism.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461257
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Yokohama City University
• Principal Investigator: ISHIGAMI Tomoaki 横浜市立大学, 医学部, 准教授 (50264651)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 食塩感受性 / 高血圧 / 上皮性ナトリウムチャネル / ユビキチン化

Outline of Final Research Achievements

According to molecular genetic analyses of both familial and hereditary hypertension by R.C.Lifton and J.M.Lalouel, imapairments of sodium reabsorption along tubules are primarily responsible for hypertension. Principal investigator performed molecular pathophysiological analyses of salt sensitivity and hypertension focusing on epithelial sodium channels and their characteristic ubiquitinating enzyme, Nedd4-2/L. We developped Nedd4-2 C2 KO mice and our analyses revealed aberrant ENaC gene activations with enhanced sodium reabsorption are basically pivotal for progression and promotion of salt sensitivity and hypertension.

Free Research Field

高血圧・食塩感受性