2017 Fiscal Year Final Research Report
THE MECHANISM OF SALT SENSITIVE HYPERTENSION IN INTERMITTENT HYPOXIA
| Project/Area Number |
26461262
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Nihon University |
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Principal Investigator |
KOYAMA Sayoko (オグラサヨコ) 日本大学, 医学部, 助教 (30618202)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIMOSAWA Tatsuo 国際医療福祉大学, 医学部, 教授 (90231365)
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| Research Collaborator |
Yeerbolati Alimila
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | 間欠的低酸素 / 食塩感受性高血圧 / NCC |
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| Outline of Final Research Achievements |
Intermittent hypoxia (IH) increases membrane protein of NCC (The thiazide-sensitive Na+-Cl－ cotransporter) in Kidney tubles. It remain by salt loading diet. The other Sodium Chrolide channel in Kidney ENaC(Epithelial sodium channel),NHE3(Na+/H+ exchange),NKCC-2(Na-K-Cl cotransporter) were not changed after IH. Challenge test of Amirolide showed no difference between Control and IH group, but Thiazide test showed remarkably increased IH group. These data suggested NCC is key for salt sensitive hypertension by IH.
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| Free Research Field |
高血圧
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