2016 Fiscal Year Final Research Report
The mechanism of axonal degeneration caused by demyelination in B7-2 KO NOD mouse
| Project/Area Number |
26461292
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 免疫介在性ニューロパチー / 動物モデル（animal model） / B7-2ノックアウト / non-obesity diabetic |
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| Outline of Final Research Achievements |
In chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), development of axonal degeneration is known as a characteristic of refractory to immune therapy and long-term poor prognosis.
An animal model of CIDP, non-obese diabetic (NOD) mouse characterized by spontaneous chronic autoimmune neuropathy is known and we confirmed the histopathological findings of NOD mouse. Mild inflammatory cell infiltration was observed from around 20 weeks of age in NOD mouse, and exhibited highly inflammatory cell infiltration with active demyelination. After the infiltration of inflammatory cells declined, secondary axonal degeneration was observed.
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| Free Research Field |
神経内科学
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