2016 Fiscal Year Final Research Report
Clinical and histological features of inflammatory myopathies mediated by autoantibodies
| Project/Area Number |
26461298
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Keio University |
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Principal Investigator |
Suzuki Shigeaki 慶應義塾大学, 医学部(信濃町), 講師 (50276242)
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| Research Collaborator |
NISHINO Ichizo
OHNUKI Yuko
WATANABE Yurika
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 自己抗体 / 炎症性筋疾患 / 免疫介在性壊死性ミオパチー |
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| Outline of Final Research Achievements |
Immune-mediated necrotizing myopathy (IMNM) is a pathological entity characterized by necrosis in the absence of prominent endomysial lymphocytic infiltration. Autoantibodies against signal recognition particle (SRP) or 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) are associated with IMNM. The frequencies of anti-SRP and anti-HMGCR antibodies in patients with IMNM were 39% and 25%, respectively. Severe limb muscle weakness, neck weakness, dysphagia, respiratory insufficiency, and muscle atrophy were more frequently observed in patients with anti-SRP antibodies than with anti-HMGCR antibodies. HLA-DRB1 genotyping revealed the association of anti-SRP antibodies with DRB1*08:03 and that of anti-HMGCR antibodies with DRB1*11:01.
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| Free Research Field |
神経内科学
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