2017 Fiscal Year Final Research Report
Research on therapy for brain infarction targeting innate immunity
| Project/Area Number |
26461301
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | 脳梗塞 / 自然免疫 / マクロファージ / DAMPs / スカベンジャー受容体 |
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| Outline of Final Research Achievements |
Immune responses following stroke appears an important factor for tissue damages. Our previous studies have shown that innate immune responses, including infiltrating macrophages and γδT lymphocytes, lead to deterioration of ischemic damages. Furthermore, we found that peroxiredoxin (Prx), an endogenous antioxidant, was identified as a novel damage-associated molecular patterns (DAMPs). Therefore, we examined the mechanisms that reduce damages from the innate immune responses after brain ischemia. We found that DAMPS were cleared by the infiltrating macrophages and transcriptional factors MAFB and class A scavenger receptor MSR1 are key factors of resolution by the macrophages. These findings indicate that targeting the innate immunity may become a novel approach for stroke treatment.
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| Free Research Field |
脳卒中学
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