2016 Fiscal Year Final Research Report
seeking the role of granulovacuolar degeneration in neurodegeneration
| Project/Area Number |
26461304
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Gunma University |
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Principal Investigator |
Yamazaki Tsuneo 群馬大学, 大学院保健学研究科, 教授 (80200658)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 顆粒空胞変性 / オートファジー / タウ / 神経原線維変化 / シアル化 |
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| Outline of Final Research Achievements |
The aim of this study is to seek the roles of abnormal protein degradation in neurodegeneration, especially Alzheimer disease. In results, we found that ubiquitin E3 ligases, Smurf1 and Tom1 are over-expressed in the disease related structures, Hirano body, dystrophic neurites and neurofibrillary tangles. We also found that over sialic acid reaction in granulovacuolar degeneration, dystrophic neurites and neurofibrillary tangles, and this reaction is strongly related to hyper-phosphorylated tau accumulation.
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| Free Research Field |
神経内科学
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