2016 Fiscal Year Final Research Report
Effects of anti-parkinsonian drugs on neural plasticity in human brain; new aspects of pathophysiological mechanisms underlying neurodegeneration.
| Project/Area Number |
26461308
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
UGAWA Yoshikazu 福島県立医大, 医学部, 教授 (50168671)
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| Research Collaborator |
TANAKA Nobuyuki
TSUTSUMI Ryousuke
SHIIMIZU Takahiro
ENOMOTO Hiroyuki
SHIROTA Yuichiro
TERADA Satomi
MATSUDA Shunichi
OOMINAMI Shinya
HAMADA Masashi
ABE Mitsuya
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 反復磁気刺激法 / 神経可塑性 / 長期増強 / パーキンソン病 |
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| Outline of Final Research Achievements |
We studied the motor cortical synaptic plasticity in human to elucidate pathophysiological mechanisms underlying neurodegenerative disorders, using a new non-invasive repetitive transcranial magnetic stimulation technique, quadripulse magnetic stimulation (QPS). First, we showed that inter-individual variability was lower in the plasticity induced by QPS than those by the other non-invasive brain stimulations in healthy volunteers. Second, we revealed that the degree of long term potentiation (LTP)-like effects induced by QPS was significantly smaller in the older participants compared to the younger participants. Third, we presented that zonisamide, one of anti-parkinsonian drugs, enhanced LTP-like effect induced by QPS in non-responders to QPS. We presented these data in academic congresses and published those in international academic journals.
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| Free Research Field |
医学 神経内科 神経生理学
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