Establishment of biomarker and clinical analysis in disuse skeletal muscle atrophy

2017 Fiscal Year Final Research Report

• Project/Area Number: 26461317
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: Wakayama Medical University
• Principal Investigator: Ken-ya Murata 和歌山県立医科大学, 医学部, 教授 (90264853)
• Co-Investigator(Kenkyū-buntansha): 伊東 秀文 和歌山県立医科大学, 医学部, 教授 (20250061) ; 西村 行秀 岩手医科大学, 医学部, 教授 (20464117) ; 高 真守 和歌山県立医科大学, 医学部, 助教 (20554629) ; 檜皮谷 泰寛 和歌山県立医科大学, 医学部, 博士研究員 (40405452) ; 廣西 昌也 和歌山県立医科大学, 医学部, 講師 (80316116)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 筋再生

Outline of Final Research Achievements

We analyzed the expression of myostatin (MSTN) and activing receptors IIB (ActR IIB) in muscle specimens from cardiotoxin injured mouse model and inflammatory myopathy.
The immunoreactivity against MSTN and ActR IIB is observed in sarcolemma and cytoplasm of Type II atrophic muscle fibers. On the other hand, the immunoreactivity against MSTN and ActR IIB is observed in cytoplasm and internal nuclei of regenerating muscle fibers. The MSTN positive ration of regenerating muscle fibers 42-49% through whole regenerating process. Both MSTN and ActR IIB positive ration in muscle fibers are very important to predict muscle atrophy.

Free Research Field

臨床神経内科学