2016 Fiscal Year Final Research Report
roles of intracellular proteolytic systems in maintaining energy metabolism homeostasis
| Project/Area Number |
26461329
|
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| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
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| Section | 一般 |
|---|
| Research Field |
Metabolomics
|
|---|
| Research Institution | Kanazawa University |
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Principal Investigator |
|
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | エネルギー代謝 / インスリン抵抗性 / 糖尿病 / 肥満症 / 脂肪肝 |
|---|
| Outline of Final Research Achievements |
To understand the roles of intracellular proteolytic systems in maintaining energy metabolism homeostasis, the present study addressed the following three unresolved issues. ①Mechanisms underlying proteasome dysfunction in obesity, ②Significance of compensatory autophagy and its substrates under inhibition of proteasome activity and starvation, ③Significance of proteasome dysfunction in skeletal muscle in insulin sensitivity
|
| Free Research Field |
内分泌・代謝内科学
|
